In the effort to check rising vision impairment worldwide, scientists
have produced a new prosthetic device that is designed to restore lost
vision.
This is contained in a study published in ‘PLOS Biology’. The
prosthetic device senses signals and transmits them to the brain by
stimulating the cells in the retina – the area at the back of the eye
that collects light focused from the lens.
The ‘bionic eye’ senses visual signals and transmits them to the
brain, but requires extensive training to help patients’ brain learn to
see again. Around the world, an estimated 40 million people are blind,
with many of them reaching this condition after years of slow and
progressive degeneration. The new study comes from researchers at an
Italian public research university, the University of Pisa, who wanted
to test the brain’s capacity to process artificial visual inputs.
They focused on seven patients with Retinitis Pigmentosa – an
inherited disease that gradually leads to complete blindness. Retinitis
pigmentosa is the name given to a group of inherited conditions of the
retina that lead to a gradual progressive reduction in vision. With the
development of this condition, difficulties with night vision and
peripheral vision are the first things that are noticed. Later, reading
vision, colour vision, and central vision are affected.
The age at which symptoms start is variable and the rate of
deterioration often varies – for example with the different genetic
types – but is generally very slow with changes occurring over years
rather than months. In approximately half of all cases, there are other
family members affected. The researchers then used functional magnetic
imaging – technology that measures brain activity by detecting changes
associated with blood flow.
This showed that patients learned to recognise unusual visual
stimuli, such as bright flashes, and this ability led to increased brain
activity. As the patient practiced seeing, the more their brain
responded to visual stimuli using the prosthetic implant.
The
researchers, led by Maria Concetta Morrone, said: “The boost in response
takes a long time and intensive training to appear, being stronger in
those subjects who used the prosthetic device more intensely and for a
longer time.”
The results suggest that after the device is implanted, the brain
undergoes plastic changes to re-learn how to process the visual signals.
The fact that after years of blindness, the brain still has some
plasticity is highly promising for the further development of new
prosthetic implants.