Eating bitter kola can reduce intraocular pressure in the
eye of healthy young adults by 21 per cent and this may be of benefit to
individuals with primary
open-angle glaucoma (POAG), which is the most common form of
glaucoma or ocular hypertension in low-income settings, a study has said.
In the new study, researchers assessed the effect of eating
bitter kola on intraocular pressure (IOP) in 46 healthy individuals aged
between 19 and 27
years at the Optometry Clinic of the University of Cape
Coast, Ghana. They were recruited from the University of Cape Coast student
population and randomised
into two groups (A and B).
Group A took 100 mg/kg body weight of bitter kola that was
mashed and dissolved in a 200 ml of water on their first visit and group B ingested
200 ml of
water. On the second visit, the order of treatment was
reversed. The IOP was measured at baseline and every 45 minutes interval for
135 minutes.
The dosage of 100 mg/kg used in this study is equivalent to
5.0 to 9.6 grammes of bitter kola and it falls within the average daily
consumption of two
nuts of bitter kola. This dosage is considered to be safe
because other scientists had speculated that high doses (400 mg/kg) of bitter
kola can be toxic
to human organs and may cause liver damage and peptic ulcer.
They had a baseline IOP measurement of between 11 and 24
mmHg in both eyes, and none of the subjects was a casual or habitual bitter
kola consumer.
Also excluded were I ndividuals that had a family history of
glaucoma, any eye or systemic disease, or were taking any forms of medication
at the time of the study.
Same too fori ndividuals that had reported allergic
reactions to bitter kola, corneal abnormalities or have potential risk factors
for angle-closure
glaucoma.
This 2020 study to determine whether eating bitter kola in a
dose comparable to normal daily consumption levels will reduce IOP
significantly in healthy
young adults had involved Alex A. Ilechie, Mohammed M.
Jeduah, Carl H. Abraham, Stephen Ocansey, Emmanuel Abu, Theophilus Okyere and
Obarijima Ngosaro.
It was in the journal, Acta Ophthalmology.
They found that the average IOP measurements decreased by
7.9, 18.2 and 20.6 per cent at 45, 90 and 135 minutes, respectively, after
bitter kola treatment.
The reduction, though variable across the individuals, was
statistically significant across the respective time points.
Glaucoma is the leading cause of irreversible blindness
worldwide. Its most common form, primary open-angle glaucoma (POAG), is
characterised by progressive
optic nerve degeneration and affects more than 60 million
people worldwide.
In Africa, glaucoma accounts for 15 per cent of blindness
and it is the region with the highest prevalence of blindness relative to other
regions worldwide.
Intraocular pressure is the only modifiable factor in
patients with glaucoma; therefore, treatment with IOP-lowering medication has
been critical to prevent
blindness.
However, the development of an active natural product that
is effective in lowering IOP and have fewer side effects might be critical to
improving glaucoma
treatment compliance.
One of such natural products is bitter kola. It is
colloquially referred to as ‘bitter kola’ because of its typical distinct
bitter taste. In Africa, bitter
kola is prevalently used for traditional hospitality and
serves a variety of roles in the treatment of several ailments including
coughs, colds, voice
hoarseness, aphrodisiac and liver diseases.
Studies have found Bitter kola has blood pressure lowering
effects. It has also shown potential utility for fighting virulent diseases,
including Ebola,
by halting viral replication. Also, there is significant
scientific evidence suggesting that bitter kola is safe in humans at the normal
consumption level.
The IOP-lowering effect of applying its water solution has
been demonstrated in both animal and human studies, including a recent
randomized clinical trial
which examined different IOP-lowering medications.